Outcomes did not differ between primary and secondary ligation groups, nor between early (& amp amp amp amp amp amp amp amp amp amp amp amp amp amp amp amp amp amp amp amp amp amp amp amp amp amp amp amp amp amp amp amp amp amp amp amp amp lt or=4 weeks, N = 52) and late ligation (& amp amp amp amp amp amp amp amp amp amp amp amp amp amp amp amp amp amp amp amp amp amp amp amp amp amp amp amp amp amp amp amp amp amp amp amp amp gt 4 weeks old, N = 30). Rates of bronchopulmonary dysplasia (BPD), severe intraventricular hemorrhage, necrotizing enterocolitis, and retinopathy were 42.7%, 32.9%, 19.6%, and 11%, respectively. The median (range) duration to return to preoperative FiO(2) was 3 (1 to 30) days and extubation was 16 (1 to 98) days. At 48 hours following ligation, an increase in fraction of inspired oxygen (FiO(2)) and ventilatory and pressor support were observed in 49 (60%), 35 (43%), and 15 (18%) infants, respectively. Ligation was the initial intervention in the primary group (N = 28) and was performed after failed medical therapy in the secondary group (N = 54). Our cohort (N = 82) had a median (range) gestational age of 25.5 (23 to 28) weeks and birth weight of 765 (484 to 1150) g. We performed a retrospective chart review. We evaluated outcomes of preterm infants following surgical ligation of patent ductus arteriosus (PDA). Overall, 11% of the infants died before being discharged from hospitals (range: 0%–21%). ![]() Gestational age and birth weight of studied infants were 28.6 ± 3.6 gestational weeks (mean ± SD) and 1025 ± 302 g, respectively. The network included 37 centers and 2145 infants weighing ≤1500 g, born or admitted to the centers in 2003. A regression model was used to predict the factors that affect neonatal mortality. A standardized mortality rate was formulated by giving a ratio of the observed deaths and the predicted deaths based on a 100-g birth weight interval mortality. A large multicenter neonatal research network that included level III NICUs from throughout Japan was established. The objectives of this study were to describe the characteristics and morbidity of very low birth weight infants, to identify the medical intervention for these infants, and to evaluate the factors affecting the mortality of these infants among the participating hospitals. On the basis of these results, paracetamol could be considered as a promising and safe therapy for the treatment of PDA in preterm infants. No adverse or side effects were observed during the treatment. Successful ductal closure was achieved in 10 out of 11 babies (90.9%). Intravenous (IV) paracetamol was given at doses 15 mg/kg every 6 h for three days. The condition of significant PDA was defined by the presence of at least one of the following criteria: internal ductal diameter # 1.4 mm/kg body weight, left atrium (LA)-to-aortic (Ao) root ratio & amp amp amp amp amp amp amp amp amp amp amp amp amp amp amp amp amp amp amp amp amp amp amp amp amp amp amp amp amp amp amp amp amp amp amp amp amp amp amp amp amp amp amp amp amp amp amp amp amp amp amp amp amp amp amp amp amp gt 1.4, unrestrictive pulsatile transductal flow, reverse or absent diastolic flow in the descending aorta along with clinical findings. Neonates with hsPDA were treated with paracetamol in the presence of contraindications to ibuprofen or indomethacin. We report a series of 11 neonates (birth weight: 415-1580 g gestational age: 23-30.3 weeks) who were treated with paracetamol for a hsPDA. ![]() The role of paracetamol has been proposed for the treatment of PDA. These drugs are associated with serious adverse events, including gastrointestinal perforation, renal failure and bleeding. Indomethacin and ibuprofen are commonly used in the treatment of hemodynamically significant patent ductus arteriosus (hsPDA).
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